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keisanHigh-precision calculations for everyday life and work

Estimating Drug Concentration

Author: Nob000889Executions: 344

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This calculation estimates drug concentrations in the body. It estimates peak and trough concentrations at steady state. (General-purpose drugs)
This calculator incorporates dosage adjustment factors based on the Giusti-Hayton method, taking into account the effects of impaired renal function and renal clearance.

Please note the following points when entering values:
1. The urinary excretion rate is expressed as a percentage. Please convert % to a decimal before entering. Example: 80% ⇒ 0.80
2. Please enter the eGFR value adjusted for the individual’s body surface area.
Half-life
h
Urinary excretion rate
eGFR
mL/min
Bioavailability
%
Molar Mass Ratio
Dosage
mg
Distribution Volume
L
Weight
kg
Dosage Interval
h
CSS (peak) µg/mL ng/mL
CSS (through) µg/mL ng/mL
Renal Function-Adjusted Css (peak) µg/mL ng/mL
Renal Function-Adjusted Css (trough) µg/mL ng/mL
Use the adjusted results only for renally excreted drugs when the eGFR is low.

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