Estimating Drug Concentration_2
Author: Nob000889Executions: 282
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This calculation estimates drug concentrations in the body. It estimates peak and trough concentrations at steady state. (Sustained-release formulations)
This calculator incorporates dosage adjustment factors based on the Giusti-Hayton method, taking into account the effects of reduced renal function and renal excretion rates.
Please note the following points when entering values:
1. Urinary excretion rates are expressed as percentages. Please convert percentages to decimal form before entering. Example: 80% ⇒ 0.80
2. Please enter the eGFR value adjusted for the individual’s body surface area.
3. When estimating the concentration of a theophylline preparation, if a corresponding drug is available, please select it from the “Theophylline Clearance Adjustment” list.
Please note the following points when entering values:
1. Urinary excretion rates are expressed as percentages. Please convert percentages to decimal form before entering. Example: 80% ⇒ 0.80
2. Please enter the eGFR value adjusted for the individual’s body surface area.
3. When estimating the concentration of a theophylline preparation, if a corresponding drug is available, please select it from the “Theophylline Clearance Adjustment” list.
| CSS (peak) | µg/mL ng/mL |
| CSS (through) | µg/mL ng/mL |
| Renal Function-Adjusted Css (peak) | µg/mL ng/mL |
| Renal Function-Adjusted Css (trough) | µg/mL ng/mL |
Use the adjusted results only for renally excreted drugs when the eGFR is low.
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